Activated prothrombin complex concentrates in the management of the hemophiliac with Factor VIII inhibitor: case report.

This report describes the management of a bleedinq episode following exodontia in a patient with severe hemophilia A and inhibitor to Factor VIII. For this patient activated prothrombin complex concentrates provided an effective method of controlling hemorrhage. Maintaining hemostasis in the surgical patient who has hemophilia A and inhibitor to Factor VIII is a difficult challenge for dentists and physicians. This report describes management of a postextraction bleeding episode using activated prothrombin complex concentrates (activated PCCs), an effective therapeutic approach not previously reported in the pediatric dental literature. Of special interest is this patient’s failure to respond to one of the available activated PCC products and his immediate response to the only other available product.